‘despite’ indicates something contrary. So, despite the rejection slips he pursues his path doggedly or tirelessly. But since the ‘and’ links similar things he is getting disappointment along with the rejection slips, not encouragement.
(doggedly = never giving up; sporadically = on and off; acclaim = praise)
The one essential ____1____ factor in a company being able to create the right customer experience that is so necessary for its continued ____2____ is its people. A company will have among its employees, planners, _____3_____, and doers. But it doesn't pay to forget that all of them are people and that their roles can never be ____4____ in a _____5____ fashion.